Approaches in Chemoprevention of Oral Cancer by Vitamin A and Green Tea
Sajjad Pourasghary
Review I Published May, 2016
Journal of Medical and Biological Science Research Vol.
2 (5), pp. 75-81
ABSTRACT
Oral cancer is one of the most common cancers which is the
6th most prevalent cancer in the world. It has been
established that incidence of cancer increases with age. The
diagnosis of oral cancer is easily possible by a visit of
the dentistry. According to various studies, oral cancer is
preventable and numerous epidemiological studies have
approved the positive effects of daily consumption of
vegetables in reducing the risk of oral cancer. Chemical
prevention is the use of drugs for prevention and
suppression of natural or precancerous cells from
transforming into cancerous cells. Vitamin A and green tea
have antioxidant properties. Various studies have confirmed
the effects of 13-cis retinoic acid in preventing dysplasia
and leukoplakia of oral cells, but other studies have shown
that the long-term use of 13-cis retinoic acid as a
preventative chemical has side effects and also, probability
of recurrence is very high. Green tea is another widely used
substance in the prevention of malignancy. In various
studies, the anticancer effects of green tea and
particularly its impact on the prevention of oral cancer has
been demonstrated. Polyphenols found in green tea are known
as inhibiting factors for the processes involved in growth
and metastasis of cancerous cells. High acceptance of green
tea and also the fact that it leaves no side effects makes
it considered as a suitable substance for chemopreventive
procedures against cancer and particularly oral cancer.
In this article we compared the effect of the vitamin A and
green tea’s effects on oral cancer prevention and care.
Key words: Chemoprevention, Oral cancer, 13-cis
retinoic acid, Green tea, Polyphenol and Vitamin A.
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