Levels of Serum Zinc and Manganese among Sudanese Patients with Thyroid Dysfunction


Rebab Osman Ahmed and AbdElkarim A. Abdrabo


Short Communication I Published February, 2016


Journal of Medical and Biological Science Research Vol. 2 (2), pp. 33-35



The objective of this study is to shed more light on the role of trace metals and their mode of action in hyperthyroidism and hypothyroidism. The content of the trace elements Zinc and Manganese (Zn and Mn) in the serum of patients was determined (Forty patients with hyperthyroidism (26 females and 14 males) and hypothyroidism (23 females and 17 males) were participated in this study. Serum zinc and manganese were determined using flame atomic absorption spectrophotometer technique. The study showed that serum zinc and manganese levels of hyperthyroidism patients were significantly lower (p<0.05) compared to reference range (zinc level is (0.5 to 1.2, mean 0.85 mg/l) and manganese is (0.3 to 0.9, mean 0.6 mg/l), While a significant increase in serum manganese level and decrease in serum zinc levels in patients with hypothyroidism (p<0.05). The present study confirmed significant changes in the levels of serum Zn, Mn in hyperthyroidism and hypothyroidism patients and these changes may be related to pathophysiology of thyroid disease.

Key words: Hyperthyroidism, Hypothyroidism, Zinc and Manganese.

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