Comparison of Vasocontractileeffects of Environmental Accumulating Material, Perfluorooctanesulfonate (PFOS) Among Isolated Rat Arteries

 

Islam, Mohammad Saiful and Yuta Kobayashi
 

 

Full Length Research Paper I Published April, 2016

 

Journal of Medical and Biological Science Research Vol. 2 (4), pp. 49-55

 

ABSTRACT

Perfluorooctanesulfonate (PFOS) and its perfluoro-analogues (PFAs) have been widely used in industrial application. The environmental persistence of PFAs has resulted in global occurrence of these substances. In the present study, vasocontractile effects of PFOS on isolated Wistar rats arterial rings were compared. Cumulative concentration response curves for PFOS (1 to 100mM) were obtained in thoracic aorta (TA), common carotid artery (CA), femoral artery (FA), pulmonary artery (PA), renal artery (RA) and supra-mesenteric artery (SMA) ring preparations. For structure-activity relationship study, PFOS was compared with perfluorooctanoic acid (PFOA), octanesulfonate (OS) or octanoic acid (OA). The most sensitive region was CA and 10 mM of PFOS showed significant contraction. The maximum contraction for PFOS on CA was larger than that of noradrenaline. Small contraction was also observed in RA, TA and SMA preparations, but not in FA and PA preparations at 100 mM of PFOS. Concerning structure-activity relationship, PFOS was the most potent compared with PFOA, OS or OA in CA preparation, suggesting the importance of carbon-fluoride structure as well as sulfonate. Present results indicated the possible toxicity of PFOS as an environmental contaminant and further studies on pollution of PFAs in the environment and biological effects of them are necessary.

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