Liver Enzymes, Urea and Creatinine among Acute Lymphocytic Leukemia in Sudanese Patients

 

Aisha Alhejazy Abdalla and Rihab Akasha
 

 

Full Length Research Paper I Published June, 2018

 

Journal of Medical and Biological Science Research Vol. 4 (2), pp. 72-75.

 

ABSTRACT

 

The aim of this study was to assess the level of AST, ALT, urea and creatinine among Sudanese patients with acute lymphocytic leukemia (ALL). Liver and renal complications occur due to several factors including leukemic cells infiltration of the liver and kidneys, therapy-related side effects such as tumor lysis syndrome, nephrotoxic drugs, and septicemia. case-control study was conducted during the period from November 2017 to February 2018, 100 participants (50 cases and 50 controls). All cases admitted to national center for radiotherapy and nuclear medicine in Khartoum State and the sample was collected by simple random sampling technique through a self-administering questionnaire, the analysis of data by SPSS version 21 using T-test for comparing mean and simple correlation for correlation of continuous numerical data. There was a significant increased in the levels of AST, ALT, urea and creatinine in patients with Acute Lymphocytic Leukemia (ALL) with p-value = 0.005, 0.003, 0.029 and 0.027, respectively when compared to healthy individuals. The Mean±SD was 73.0±42.2 U/L, 85.1±34.8), 40.9±22.8 and 1.4±0.88mg/dl in ALL patients, respectively and was 32.5±8.5U/L, 25.2±7.6, 29.2±9.1 and 0.92±0.39mg/dl in healthy individuals, respectively, Also there was significant increased in the levels of AST and ALT in male with ALL when compared with female with ALL, the p-value was 0.028 and 0.025 respectively, also there was a positive correlation between level of AST and age in (ALL) patients with (R= 0.307, p-value= 0.030). But there was no correlation between the levels of ALT, urea and creatinine with age. The levels of AST, ALT, Urea and creatinine was increased in patients with ALL when compared to healthy individuals, and also there was positive correlation between AST level and age.

Key words: Acute lymphocytic leukemia (ALL), liver enzymes, Khartoum State.

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