Evaluation of Time-Dependent Effects of a Leaf Extract of Spermacoce Ocymoides on Kidney Function
Nwachukwu Francis Chukwuedozie
Full Length Research I Published May, 2016
Journal of Medical and Biological Science Research Vol.
2 (5), pp. 68-74
ABSTRACT
Increase use of herbal medicines for the treatment of
various diseases is suspected to cause renal toxicity. The
study evaluated time-dependant effects of daily
administration of leaf extract of Spermacoce ocymoides
on renal function. The albino rats were grouped into two
groups viz: control and treatment groups. The standard
methods, as reported by;
Butler,
Evans, Vogel, Hochestrasser and
Bassir, and
Skeggs were employed in the in vivo estimation of
serum kidney function.
The results revealed increased significant difference, in
the concentrations of serum creatinine, and urea as compared
with the control untreated, at P < 0.05, on the fourteenth
and eighteenth day. Chloride ion concentrations were
significantly different (P <0.05) on the second, tenth and
eighteenth day of administration, as compared with the
control, however serum bicarbonate ion was not significant,
only on fourteenth day, as compared with control. There were
no significant changes in serum potassium and sodium ion
concentrations. At the end of research: urea (246%) and
creatinine (62%) were poorly excreted while, chloride ions
(51%) was poorly regulated. Sodium and potassium ion have
the least percentage fluctuations (5 and 7%). The fourteenth
and eighteenth day of the daily administration of the leaf
extract caused kidney impairment and by inference contains
nephrotoxin.
Key words:
Creatinine, Electrolyte, Kidney, Urea and Spermacoce
ocymoides.
- Journal of Agricultural Science and Food Technology (JASFT)
- Journal of Medical and Biological Science Research (JMBSR)
- Journal of Scientific Research and Essays (JSRE)
- Research Journal of Educational Studies and Review (RJESR)
- Journal of Physical Science and Environmental Studies (JPSES)
- Research Journal of Engineering and Technology (RJET)
- Pearl Journal of Management, Social Science and Humanities (PJMSSH)