Evaluation of Iron Profile in Sudanese with Rheumatoid Arthritis


Noha Mohamed Saeed, Salih A. Elmahdi, Gadalla Modawe and AbdElkarim A. Abdrabo


Full Length Research Paper I Published March, 2016


Journal of Medical and Biological Science Research Vol. 2 (3), pp. 44-48



Anemia adds considerably to the morbidity in patients with rheumatoid arthritis (RA). Iron has many important functions in human body. This study aimed to evaluate the level of blood indices, serum Iron and Total Iron Binding Capacity (TIBC) and their correlation with durations and complications of disease. This is cross-sectional study involved 48 patients with rheumatoid arthritis disease. The serum level of iron and total TIBC were estimated by the automated chemistry analyzer (COBAS-plus 400), blood indices by automated hematology analyzer (Sysmex). The analysis of the results indicated that the means level of iron, TIBC, hemoglobin, mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC) were significantly lower than the reference value, while hematocrit (HCT) results revealed insignificant change. Positive correlations were found in MCH, HCT and duration of disease. All hematology parameters levels were insignificantly correlated with complication of disease. The results observed that the levels of serum iron, TIBC, MCH and Hb was significantly decreased in patients with Rheumatoid arthritis when compared to reference value. Insignificant correlation observed between level of these elements and complication of RA disease, and significantly increases level of HCT, MCH in long duration patient group.

Key words: Rheumatoid, Iron, TIBC and Sudan.

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