Hypocholesterolemic and Hypoglycaemic Effects of Ethanolic Extract Of Leaf of Moringa Oleifera Lam in High Fat Diet Fed Wistar Rats


Sule, O.J. and Arhoghro, E.M


Full Length Research Paper I Published June, 2016


Journal of Medical and Biological Science Research Vol. 2 (6), pp. 109-113



Hypocholesterolemic and hypoglycaemic activity of ethanolic extract of Moringa oleifera leaves was assessed. Thirty male Wistar albino rats were used, comprising of five groups of six animals each. Rats in groups (1 to 4) were fed with formulated fatty diet mixed with grower’s match, while rats in group 5 were fed with grower’s match only for fifteen day. Rats in groups 2, 3 and 4 were treated with extracts of M. oleifera (100, 200 and 300 mg/kg), respectively for ten days, while group 5 received normal saline for ten days. Blood samples were collected from the tail of animals on days 15 and 25 of the study. Samples were used to determine the cholesterol and glucose concentrations using standard kits. Weight changes were also determined. The results showed significant increases in the weight, cholesterol and glucose levels of rat fed with high fatty diets without extract compared to rats in normal group. Also, there was significant decrease in the levels of these parameters in rats fed with fatty diets with extracts, compared to untreated group. Conclusively, the leaves of M. oleifera may possess hypocholesterolemic and hypoglycemic activity and may be the basis for exploring its medicinal values by the traditionalist especially in Nigeria.

Key words: Hypocholeterolemic, Hypoglycemic and Moringa oleifera.

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