Hypocholesterolemic and Hypoglycaemic Effects of Ethanolic Extract Of Leaf of Moringa Oleifera Lam in High Fat Diet Fed Wistar Rats
Sule, O.J. and Arhoghro, E.M
Full Length Research Paper I Published June, 2016
Journal of Medical and Biological Science Research Vol.
2 (6), pp. 109-113
ABSTRACT
Hypocholesterolemic and hypoglycaemic activity of ethanolic
extract of Moringa oleifera leaves was assessed.
Thirty male Wistar albino rats were used, comprising of five
groups of six animals each. Rats in groups (1 to 4) were fed
with formulated fatty diet mixed with grower’s match, while
rats in group 5 were fed with grower’s match only for
fifteen day. Rats in groups 2, 3 and 4 were treated with
extracts of M. oleifera (100, 200 and 300 mg/kg),
respectively for ten days, while group 5 received normal
saline for ten days. Blood samples were collected from the
tail of animals on days 15 and 25 of the study. Samples were
used to determine the cholesterol and glucose concentrations
using standard kits. Weight changes were also determined.
The results showed significant increases in the weight,
cholesterol and glucose levels of rat fed with high fatty
diets without extract compared to rats in normal group.
Also, there was significant decrease in the levels of these
parameters in rats fed with fatty diets with extracts,
compared to untreated group.
Conclusively, the leaves of M. oleifera may possess
hypocholesterolemic and hypoglycemic activity and may be the
basis for exploring its medicinal values by the
traditionalist especially in Nigeria.
Key words: Hypocholeterolemic, Hypoglycemic and
Moringa oleifera.
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