Levels of Serum Zinc and Manganese among Sudanese Patients with Thyroid Dysfunction
Rebab Osman Ahmed and AbdElkarim A. Abdrabo
Short Communication I Published February, 2016
Journal of Medical and Biological Science Research Vol.
2 (2), pp. 33-35
ABSTRACT
The objective of this study is to shed more light on the
role of trace metals and their mode of action in
hyperthyroidism and hypothyroidism. The content of the trace
elements Zinc and Manganese (Zn and Mn) in the serum of
patients was determined (Forty patients with hyperthyroidism
(26 females and 14 males) and hypothyroidism (23 females and
17 males) were participated in this study. Serum zinc and
manganese were determined using flame atomic absorption
spectrophotometer technique. The study showed that serum
zinc and manganese levels of hyperthyroidism patients were
significantly lower (p<0.05) compared to reference range
(zinc level is (0.5 to 1.2, mean 0.85 mg/l) and manganese is
(0.3 to 0.9, mean 0.6 mg/l), While a significant increase in
serum manganese level and decrease in serum zinc levels in
patients with hypothyroidism (p<0.05). The present study
confirmed significant changes in the levels of serum Zn, Mn
in hyperthyroidism and hypothyroidism patients and these
changes may be related to pathophysiology of thyroid
disease.
Key words: Hyperthyroidism, Hypothyroidism, Zinc and
Manganese.
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