Incidence and Evaluation of Stress Induced In Plasmodium Falciparum Malaria Infected Individuals Using Cortisol, Malondialdehyde, Blood Glucose and Lipid Profile Level


Esan A.J.


Full Length Research Paper I Published December, 2016


Journal of Medical and Biological Science Research Vol. 2 (10), pp. 158-162



The aim of this study was to evaluate stress induced in Plasmodium falciparum malaria parasite infected individuals using cortisol, malondialdehyde, blood glucose and lipid profile level. The study was conducted at Federal Teaching Hospital, Ido-Ekiti, Nigeria. Two hundred and two blood samples were collected twice from the same malaria infected individuals; the patients were placed on artemether and lumefantrine combine therapy. Thick blood film was made from EDTA blood sample and stained with Giemsa staining technique for malaria parasite detection, the procedure was described by routine manual method. Cortisol was estimated using Enzyme Linked Immunosorbent Assay method by Monobind Inc. Malondialdehyde (MDA) was estimated using thiobarbituric acid method by Tomotsu; blood glucose level was estimated using glucose oxidase method and blood lipid profile was also estimated using randox kit. Data obtained was analyzed using SPSS version 16. The mean ± SE of cortisol, MDA, blood glucose, low density lipoproteins (LDL) and triglyceride in pre treatment were significantly (p<0.05) higher compared to post treatment and control (in each case). This study shows that Plasmodium falciparum malaria induces stress especially in acute malaria infected individuals. However, during malaria treatment, the level of stress induced by malaria parasite was decline as the clinical condition improves due to the effect of anti-malaria drug used as observed in the study.

Key words: Malaria parasite, Stress induced and Anti-malaria therapy.

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