Comparison of Vasocontractileeffects of Environmental Accumulating Material, Perfluorooctanesulfonate (PFOS) Among Isolated Rat Arteries
Islam, Mohammad Saiful and Yuta Kobayashi
Full Length Research Paper I Published April, 2016
Journal of Medical and Biological Science Research Vol.
2 (4), pp. 49-55
ABSTRACT
Perfluorooctanesulfonate (PFOS) and its perfluoro-analogues
(PFAs)
have been widely used in industrial application.
The environmental persistence of PFAs has resulted in global
occurrence of these substances. In the present study,
vasocontractile effects of PFOS on isolated Wistar rats
arterial rings were compared.
Cumulative concentration response curves for PFOS (1 to 100mM)
were obtained in thoracic aorta (TA), common carotid artery
(CA), femoral artery (FA), pulmonary artery (PA), renal
artery (RA) and supra-mesenteric artery (SMA) ring
preparations.
For structure-activity relationship study, PFOS was compared
with perfluorooctanoic acid (PFOA), octanesulfonate (OS) or
octanoic acid (OA). The most sensitive region was CA and 10
mM
of PFOS showed significant contraction.
The maximum contraction for PFOS on CA was larger than that
of noradrenaline. Small contraction was also observed in RA,
TA and SMA preparations, but not in FA and PA preparations
at 100
mM
of PFOS. Concerning structure-activity
relationship, PFOS was the most potent compared with PFOA,
OS or OA in CA preparation, suggesting the importance of
carbon-fluoride structure as well as sulfonate. Present
results indicated the possible toxicity of PFOS as an
environmental contaminant and further studies on pollution
of PFAs in the environment and biological effects of them
are necessary.
Key words: Associates, Blood, Crime, Informants,
Reliability, Academy.
- Journal of Agricultural Science and Food Technology (JASFT)
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- Pearl Journal of Management, Social Science and Humanities (PJMSSH)