Interrelation between Helicobacter Pylori Infection, Infantile Colic, and Irritable Bowel Syndrome in Pediatric Patients

 

Abdelrazak MA, Walid FE, M Abdelrahman and Mohamed Abdeltawab Mahmoud

 

Research Paper I Published September,2015

 

Journal of Medical and Biological Science Research Vol. 1 (7), pp. 85-91

 

ABSTRACT

To determine whether irritable bowel syndrome is associated with Helicobacter pylori infection and infantile colic. A retrospective case controlled study was conducted in Abha hospital (Saudi Arabia), Abo Hariz Hospital, (Sharkia, Egypt), and Al Hussein University Hospital (Cairo, Egypt). 450 cases of irritable bowel syndrome (IBS) that met the Rome III criteria and 100 controls (IBS-negative), aged 7 to 17 years old, were involved in this study. Complete stool analysis including H. pylori stool antigen test and occult blood in addition to urea breath test, were carried out for all participants.Of the total 450 IBS cases, 212 (47.1%) had reported infantile colic at age 0 to 4 months compared to 7 (7.0%) in control group, and family history of IBS was evident in case group (n = 315; 70.0%) versus control group (n = 10; 10.0%). Furthermore, H. pylori was present in 192 (42.7%) of IBS cases compared to only 8 (8.0%) in control group. Our findings provide a new correlations between childhood IBS and infantile colic as well as H. pylori infection. Moreover, a significant association was found between IBS and family history of IBS. 1-the relationship between H pylori and infantile colic and 2-H pylori and adult IBS are the known while what is new is 1- Correlation between childhood IBS and infantile colic, 2- Correlation between childhood IBS and H. pylori infection and 3- A significant association between childhood IBS and family history of IBS.

Key words: Helicobacter pylori, Rome III Criteria, Stool Antigen Test and Colic.

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