Does A Singular Exposure Of Male Albino Rats To Kerosene Affect The Liver?
Nwachuku, E.O., Okolonkwo, B.N, Bartimaeus and E.S, Brisibie, N
Research Paper I Published October,2015
Journal of Medical and Biological Science Research Vol.
1 (8), pp. 112-117
ABSTRACT
This study evaluated the toxic effect of kerosene on the
liver of male rats within 24 h of acute exposure. The
kerosene samples total hydrocarbon analysis by gas
chromatography revealed that kerosene contained C12 to C16
carbons and a total hydrocarbon content of 65,332 mg/L. The
rats were intraperitioneally injected with kerosene at
different dose levels (22.2, 44.2, 88.9 and 177.8g/kg
kerosene) following the determination of LD50 of kerosene as
86.7g/kg. The rats were observed within 24 h for signs and
symptoms of toxicity, and approximate time in minutes of
occurrence of each symptom noted. The appearance and
severity of symptoms were dose dependent. The onset of
symptom which was fast (within 1 h of injection) occurred
only at fairly high doses. The results indicated that
exposure to kerosene is potentially toxic and the degree of
toxicity and onset of symptoms were influenced by the dose
to which the rats were exposed. The biochemical parameters
Aspartate transaminase (AST), Alanine transaminase (ALT),
and Alkaline phosphatase (ALP) studied showed significant
dose dependent increases in levels, P < 0.001, indicating
hepatic damage. This study has shown that exposure to
kerosene is toxic to the liver and its severity is dependent
on the dose of exposure.
Key words:
Biochemical parameters, Intraperitoneal, Kerosene, Liver,
Rats and Toxicity.
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