JMBSR-Abstract

Does A Singular Exposure Of Male Albino Rats To Kerosene Affect The Liver?

 

Nwachuku, E.O., Okolonkwo, B.N, Bartimaeus and E.S, Brisibie, N

 

Research Paper I Published October,2015

 

Journal of Medical and Biological Science Research Vol. 1 (8), pp. 112-117

 

ABSTRACT

This study evaluated the toxic effect of kerosene on the liver of male rats within 24 h of acute exposure. The kerosene samples total hydrocarbon analysis by gas chromatography revealed that kerosene contained C12 to C16 carbons and a total hydrocarbon content of 65,332 mg/L. The rats were intraperitioneally injected with kerosene at different dose levels (22.2, 44.2, 88.9 and 177.8g/kg kerosene) following the determination of LD50 of kerosene as 86.7g/kg. The rats were observed within 24 h for signs and symptoms of toxicity, and approximate time in minutes of occurrence of each symptom noted. The appearance and severity of symptoms were dose dependent. The onset of symptom which was fast (within 1 h of injection) occurred only at fairly high doses. The results indicated that exposure to kerosene is potentially toxic and the degree of toxicity and onset of symptoms were influenced by the dose to which the rats were exposed. The biochemical parameters Aspartate transaminase (AST), Alanine transaminase (ALT), and Alkaline phosphatase (ALP) studied showed significant dose dependent increases in levels, P < 0.001, indicating hepatic damage. This study has shown that exposure to kerosene is toxic to the liver and its severity is dependent on the dose of exposure.

Key words:
Biochemical parameters, Intraperitoneal, Kerosene, Liver, Rats and Toxicity.

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