Alterations of Homocysteine in Sickle Cell Anaemia
Nnodim Johnkennedy1*,Udujih Bernard Uche2,
Nwaokoro Joakin Chidozie3, Uche Ukonu1
and Onah Christian4
Short communication I Published June,2015
Journal of Medical and Biological Science Research Vol.
1 (4), pp. 44-46
1Department of Medical Laboratory Science, Faculty of Health Science, Imo State University Owerri,Nigeria.
2Department of Obstetrics and Gynecology, Specialist Hospital Owerri, Imo State, Nigeria.
3Department of Public Health Federal University of Technology Owerri, Imo State, Nigeria.
4Department of Chemical Pathology Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.
*Corresponding author E-mail:johnkennedy23@yahoo.com.
Abstract
The serum homocysteine levels of sickle cell patients
attending General Hospital Owerri, Nigeria were evaluated to
determine whether or not the serum levels of these
homocysteine were normal. One hundred confirmed sickle cell
patients (HbSS), and thirty sickle cell patients in crisis
age 5 to 30 years were selected. One hundred normal subjects
(HbAA) age 5 to 30 years were used as control. The mean
level of homocysteine was significantly increased in sickle
cell anaemia (p<0.05), when compared with the control (HbAA).
However, the mean level of homocysteine was significantly
more increased in sickle cell crisis compared with sickle
cell anaemia. The result suggests, that sickle cell anemia
is linked with elevated homocysteine level, which could lead
to increased risk of hypercoagulability and thromboembolic
complications as well as cardiovascular risk in sickle cell
anaemia.
Key words: Homocysteine, Sickle cell anaemia, General
Hospital, Owerri.
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