JMBSR-Abstract

 

Alterations of Homocysteine in Sickle Cell Anaemia

 

Nnodim Johnkennedy1*,Udujih Bernard Uche2, Nwaokoro Joakin Chidozie3, Uche Ukonu1 and Onah Christian4
 

Short communication I Published June,2015

 

Journal of Medical and Biological Science Research Vol. 1 (4), pp. 44-46

 

1Department of Medical Laboratory Science, Faculty of Health Science, Imo State University Owerri,Nigeria.
2Department of Obstetrics and Gynecology, Specialist Hospital Owerri, Imo State, Nigeria.
3Department of Public Health Federal University of Technology Owerri, Imo State, Nigeria.
4Department of Chemical Pathology Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.
 

*Corresponding author E-mail:johnkennedy23@yahoo.com   

 

Abstract

 

The serum homocysteine levels of sickle cell patients attending General Hospital Owerri, Nigeria were evaluated to determine whether or not the serum levels of these homocysteine were normal. One hundred confirmed sickle cell patients (HbSS), and thirty sickle cell patients in crisis age 5 to 30 years were selected. One hundred normal subjects (HbAA) age 5 to 30 years were used as control. The mean level of homocysteine was significantly increased in sickle cell anaemia (p<0.05), when compared with the control (HbAA). However, the mean level of homocysteine was significantly more increased in sickle cell crisis compared with sickle cell anaemia. The result suggests, that sickle cell anemia is linked with elevated homocysteine level, which could lead to increased risk of hypercoagulability and thromboembolic complications as well as cardiovascular risk in sickle cell anaemia.

Key words: Homocysteine, Sickle cell anaemia, General Hospital, Owerri.

 

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