Cadmium Status and Activities of Cardiac Marker Enzymes in Smokers: Using Experimental Animals Model
Agbaogun B.K.O and Babalola O.O.
Research Paper I Published December,2015
Journal of Medical and Biological Science Research Vol.
1 (10), pp. 179-182
ABSTRACT
This study was designed to determine blood cadmium
concentration and the activities of selected cardiac marker
enzymes in two different groups of smokers, using
experimental animal model. Twelve wiener rabbits were
randomly distributed into 3 groups of 4 animals each. Groups
I and II animals were exposed to smoke from two different
brands of cigarette commonly consume in Nigeria for a period
of three weeks. Each animal in the test groups was treated
with six sticks of cigarette per day in an inhalation
chamber. Group III animals served as the controls were
exposed to normal air. At the end of the test period, the
animals were sacrificed. The blood samples were collected
and blood Cadmium concentration (bCd) were determined by
Atomic Absorption Spectrophotometry, activity of Lactate
Dehydrogenase (LDH) and Creatinine Kinase (CPK) were
analysed in the plasma by standard colorimetric technique.
The lungs of the animal were also excised for histological
studies. The results obtained revealed an increase in the
mean activity of LDH and CPK in the test groups when
compared with the control. There is significant increase in
the mean concentrations of LDH and CPK between Group II and
controls. (P ≤ 0.05), but the increase is not significant
between group I and controls. Also, the histological
pictures of the test animals revealed evidence of lungs
pathology. This results suggesting that cigarette smoking
has associated health hazards, and thus added to the
avalanche of overwhelming evidences against cigarette
smoking. However this is not clearly manifested in the
activities of the enzymes associated with cardiac functions.
Key words: Cigarette, Cardiac enzymes, Smokers and
Cadmium.
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